Thanks for all the responses. The hotel I'm talking about is the Copley Square Hotel in Boston, MA. The room pictures on the hotel's website are nowhere near the room we received. We were put in a room with two twins on the 2nd floor.
I've initiated a dispute with my credit card company. I'll contact Priceline to inquire about a refund while the paperwork arrives, and if they haven't agreed to a reasonable refund, I'll continue the dispute with my credit card company.
Upon checkin, we were provided with a room that was already occupied. It was listed in the reservation as a vacant room, but someone had extended their stay without notifying the hotel. Thus when we got to our initial room and opened the door (at around 8pm), we surprised some lady who was already in there. Is this something that I should mention in my comments to Priceline as well? I could see it happening at other hotels, but it does say something about the security at the hotel.