Thanks all.

Looks like I can make the switch to SNA with CO outbound and NW inbound. Leave DTW later, still get into SNA around 4:30PM and get back home around 9:30PM after connecting thru MSP. Should be the same $75 change/cancel fees.

Rental cars initially looked pricier, but if I switch from Thrifty to Enterprise I can keep the $120/wk rate for a full-size or move to a minivan for $175/wk (Thrifty was $170/wk at LAX or ONT).

Sounds like we have a winner! (unless someone can get me a helicopter that will land right at the Embassy Suites Anaheim South)

I think the wife'll even go for this itinerary. She gave me a baaaad look when I said 6:00 AM departure.