I am very surprised by some of the responses in this thread - personally I consider sitting (and sleeping) comfort by far the most important amenity on a flight. I find it impossible to sleep in a coach seat and those of you who can are very lucky (I seriously envy you). I really am intrigued that people value the airline food and entertainment, even in business so highly - I assume that means you feel physically comfortable in either class.
Novacats suggestion certainly has merit. I am also intrigued by Kokonutz idea about the daytime US-Europe flights. I have always considered that a waste of another day, so does anyone else have any comments?