Is it still possible that some 757s could be reactivated if demand comes back for some long/thin routes to Europe? The A321LR can likely fly from PHL to the British Isles, but a lot of smaller continental Europe destinations would be off the table.
One of the more subtle things to notice is the lack of a stepped climb on take-off, like the 737 has to. Boeing ultimately chose the wrong aircraft to develop into its workhorse, though the 757 was massively over-engined and over-winged, the 737 really can barely fly transcons.