For context, I'm 40 and have two kids under age 3. I'm writing this from a crappy Hampton Inn in Peoria.
Before my kids were born I traveled four to six times a month (mostly within North America) for work. I loved it...most of the time. Once my first daughter reached about six months and was really interacting with me, I realized that I didn't like leaving her that frequently. That made me make some changes to my work and now I travel only twice a month.
If you do take the job, get a nanny if you can. Even if you can only afford help once or twice a week, you will reap huge dividends from it. Family and friends are great to have around, but it's not the same as having someone whose livelihood depends on showing up to help take care of the kids.
Should you take the job? Only you and your wife can answer that. My gut says, unless it's a life-changing amount of money, this is not the time to do it.