Some close friends were in a similar position a few years ago, with initially one and then two little ones. The husband would leave home late Sunday for a redeye from the West Coast of the USA to the East Coast, and would get home around midnight on the Friday. So, few full weekends away, but only one week in 10 at home, so perhaps more weekdays away. They managed for the first few years (not sure how, but they were always cheery about it), with the wife going to part time and relying on a close network of her adult friends, along with fellow new mothers. But once the older one was about two or three, the husband found that he couldn't face the time away, both missing the company of the toddler, and concerned that he was not really part of her life. So, he changed jobs, with less, but more distant, travel.