My wife, who works for a large Pharma company here in Brisbane, often attends meetings in Sdney, and will get the 7:00 am flight for a 9:00 am meeting in North Ryde, then gets back to Brisbane by about 6:00 pm. We don't live far from the airport (9 minutes, when we realised that we were really late one day- wouldn't reccomend that though). She has done this up to 3 times a week, mon, wed, fri. but will take a change of clothes just in case she gets held over.
She is generally pretty tired but it beats living in SYD!!!!
Best of all her PA books FULL Y for her, stacking up the SCs faster than the empty HP's at the QP at the BNE FT AGM.