Well, we are talking Rochester, NY...so if you want a "nice" restaurant, your only option is to stay in Pittsford, which is where The Del Monte is.
If you're looking slightly less posh, I usually stay at the Residence Inn in Greece, NY. It's centrally located next to 390. Walking distance to The Distillery, Applebee's (meh), and Olive Garden (meh). It's also close (driving distance) to Wegman's & the Greece Mall. It's only a 10 minute drive from the epitome of haut cuisine in Rochester, Nick Tahou's, home of the Garbage Plate.