No one can really give you a definite answer until you tell us what kinds of activities you like to do.
You could spend the whole long weekend inside microbrewery tasting rooms across the front range.
You could go hiking or biking--maybe in shorts, maybe in snow gear, maybe in both the same day/weekend.
CU has two home games in November. NBA and NHL will also be in full swing.
You could chill all weekend and take advantage of Colorado marijuana laws.