You can use https://www.uber.com/fare-estimate/ to figure it out the cost and google maps to figure out an estimated duration. I’d guess it to be 75-120 minutes, on average, depending on the time of day and traffic.

The previous estimate of Van Nuys to RC Laguna Niguel being $45-55 is sadly in error; it would be more in the range of $105-125 if I had to guess, as agreed also by the estimator.