Full name on passport = Last, First and Middle
Name on ticket and FFP = First and Last
Have been flying to many different countries, including the US international and domestic, without any issue for more than two decades. There was only one time at TPE, CX ground agent questioned that name on my ticket did not match full name on passport. Told her not to worry, that's the middle name. It seems that a lot of people in Taiwan (or Chinese speakers in general?) do not have the concept of the "middle name"?
This also applies to GE/TSA Pre, where my profile name matches my full name on passport. I do get TSA Pre fine when the reservation name only shows my First and Last.