Originally Posted by findark

6DE are strictly superior to 2DE. Barring that, I think it depends on your preferences. Sure, "not being stepped on" is nice but it's not that hard to get out of the window seat and I can't imagine it's a big deal if the person doing it is your wife.

I would not say that the "small" cabin offers anything in terms of privacy or noise; anything you gain from 2 fewer rows is lost from being closer to Y. Row 6 does have substantially bigger footwells though. Namely, I would never take 7/8 DE over 2DE, but I would consider 6AB or 6KL.

For me, 1A is my favorite seat on the plane.