Consider the town of Napa.
Andaz Napa was just redone after the earthquake a couple of years ago.
1800 First is a nice boutique hotel disguised as a B&B in a Victorian about 10 minutes pleasant stroll from downtown.
Oenotri - right across the street from the Andaz -is good for casual dining.
Morimoto Napa for a more memorable meal.
Some people turn their noses up at Napa, usually dropping St. Helena or Yountville as preferences. Napa is a more "real" town than those, which (imo) are essentially upscale tourist towns.
Depends on what you like.