Good accomodation you can book on booking.com or airbnb, cause it will be cheaper that a hotel. Each museum has audioguide, so there will be no problem. Good guide you can find on tripster, and I personally can recommend good clubs for nightlife LUXbar, Zavistbar with its show and maybe 7sky. There are a lot of clubs, bars and restaurants, but that is quite good, you won't want to return to the hotel
So, good luck with your travel.