Check the schedules closely too. Some flights to/from Alaska are red-eyes, and red-eyes are not that comfortable for many people on domestic planes (even if first class, since the domestic planes' first class seats are not really designed for sleeping). So if you want them to be comfortable, make sure you research which connections on which airlines are doable on daytime flights (and make sure there's award availability on those flights, not just on some randomly-timed flights).