Originally Posted by
Villavic
Well Cusco is three times that altitude, so there's a considerable difference. But if you didn't have issues at higher elevations, you'll probably be fine.
Wether you spend time at Cusco city at beginning or end of the trip, I do recommend enjoy it anyway. There are lot of beautiful places to see at Cusco (temples, churches, narrowed streets, etc.).
+1. We spent only a few hours, at the very end of the trip. Definitely a city worth more time to explore. The altitude felt fine at the end, much better than when we stepped off the plane and waited for our driver. If possible, use a combo driver/guide and you'll gain more appreciation for what you're seeing. Don't think it was worth the 45 minutes doing the tour inside the cathedral on the square though (would have been fine if we had more time in Cusco).