Another +1 on US-DXB or anywhere in the Gulf. Sometimes I can use RJ or the EY codeshares. QR will be a big help. But an AA flight would be great for using SWUs or other upgrades. This will also be badly needed if any new rules for elite qualification come up that require spending on AA metal.
If UA and DL can maintain non-stops to this part of the world then I don't see why AA can't.