I'm no expert, but look into your destinations. Not every chain has hotels in every place. After that, consider the spending categories on the card and night availability. A lot of people are down on Hilton due to devaluation for high-end properties. Although I think AXON awards (if you have the AMEX) are a good value. And there is a 60k Hilton Hhonors Amex available ($750 min spend).

Also, another thing to note is that Priority Club/IHG points don't expire and Hilton Hhonors points will only expire if you do not have activity for 12 consecutive months, so you can extend life by buying points, going through the shopping mall, or any other non-stay partner. So even if they're not you're number one partner, it's easy to keep those two programs going.