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Old Sep 17, 2011, 8:36 pm
  #4  
Lurker1999
 
Join Date: Apr 2006
Location: BOS
Posts: 3,534
http://products.sanofi.us/ambien_cr/ambienCR.html

Ambien CR (sustained release) has a 17% increase in half-life over Ambien only.

12.3 Pharmacokinetics
Ambien CR exhibits biphasic absorption characteristics, which results in rapid initial absorption from the gastrointestinal tract similar to zolpidem tartrate immediate-release, then provides extended plasma concentrations beyond three hours after administration. A study in 24 healthy male subjects was conducted to compare mean zolpidem plasma concentration-time profiles obtained after single oral administration of Ambien CR 12.5 mg and of an immediate-release formulation of zolpidem tartrate (10 mg). The terminal elimination half-life observed with Ambien CR (12.5 mg) was similar to that obtained with immediate-release zolpidem tartrate (10 mg). The mean plasma concentration-time profiles are shown in Figure 1.
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