I'm not a fan of hand lotion because it's just too thin and thus doesn't really do the job IMHO. My favorite is the Body Shop's Vitamin E Body Butter. I actually keep in the refrigerator.
Things that I also like are L'Occitane's shea butter hand cream and the tins of 100% pure shea butter when I travel. Shea butter is an ingredient that will help keep your hands better moisturized. If your hands are REALLY dry, use 100% pure shea butter initially.