I'm a big proponent of the Eagle Creek products. On all trips I use their shirt cube, which I find keeps my shirts wrinkle-free and tidy, and I take a small zippered cube for smaller items like socks, underwear and belts and any accessories (gym watch, etc.). If it's a longer trip, I often take a third cube for other clothes like pants and shorts. The cubes do a great job of keeping things organized and fairly compressed and wrinkle-free.