22 x ITM-TJH (TAJIMA) on Tokubin 1 fare @ 7,900 yen each
Miles = 53 * 22 * 2 (2x miles promotion) = 2,332 miles
FOPs = (53 * 120% (JALCard promotion) + 400) * 22 = 11,594 FOPs
Cost = 7,900 * 22 = 173,800 yen
28 x ITM-TJH (TAJIMA) on Birthday fare (@6,500 yen each)/Sakitoku fare (@6,900 yen each)
Miles = 53 * 28 * 2 (2x miles promotion) = 2,968 miles
FOPs = 53 * 120% (JALCard promotion) * 28 = 3,556 FOPs
Cost = 6,500 * 28 = 182,000 yen (Birthday) or 6,900 * 28 = 193,200 yen (Sakitoku)
Total Cost: 355,800 yen (with Birthday fare) or 367,000 yen (with Sakitoku fare). It can go even lower with Shareholder discount but let's not go there 
Total Sectors: 50
Total FOPs: 15,150 (> min 15,000 requirement)
Total Miles: 5,300 (obviously not the best for miles per yen)