The Vacation Club is really a super-desirable location and should be your top choice, everything else being equal. Harbor Beach is off the beaten track -- not my choice, even ignoring the renovations. Hyatt Pier 66, which you considered, is only slightly closer to the beach than Marriott's Marina Hotel (just across the Intracoastal on 17th Street). If you prefer Marriotts and don't care too much about being directly on the beach, the Marina is a good candidate. You'll save some money. They have a shuttle bus to the beach, incidentally.
Bruce