Probably matters a lot on your origin/destination. Why don't you try a few dummy bookings for the same flight on Saturday, Sunday, and Monday? - this will give you a good indication of the demand on the various days
I've always found over Easter weekend flying to/from hubs like SFO, ORD:
Thursday & Friday - Heavy loads
Saturday - Light loads
Sunday - AM light, PM heavier, though not the usual Sunday rush
Monday - AM heavy, PM normal
hmmm, last Easter I was on a 6:45am SFO-ORD. It was a overbooked 744 so I got upgraded, lucky me. That plane was completely full, as was the rest of the airport to my surprise. My ORD-MHT wasnt exactly empty either, although not full to the brims like my earlier flight had been.