Making change to ticket with confirmed *A upgrade

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I am ticketed on a set of flights, including two with confirmed *A upgrades. I need to make a change, one that will require a reticketing.

The issuing carrier is not the carrier with the upgrades. Nor is it the program that is sponsoring the upgrade. In fact, the flights that are upgraded are not affected by the change at all.

So, if I make a change, will the upgrades be affected?

Any of this make sense?
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