I am trying to rent a large (5-6 bedroom) villa in the Caribbean over Thanksgiving (prefer St. Thomas or St. John but will consider any island). Can anyone recommend a good rental agency for this sort of thing? Thanks.

I used these folks last year on a trip to St John. We had no problems with them and they assisted us with the car rental too. Let me know if you have any quesions about St John.
http://www.caribbeanvilla.com