How about a trip away with the girls? Rent a houseboat or a motorhome and send them to a music festival somewhere - you can go quite upscale with a motorhome.
I prefer "event-type" gifts, as you have such wonderful memories forever. Also - what about an up to date family portrait? If she is interested in wine - why not adopt a row of grapes for a year? You get 12 bottles and a little sign at the end of the row, as well as a VIP party to attend.
And anything that comes in that little blue box...no one can have enough from Tiffany's can they?