Originally Posted by slippahs
I'm not a SFO native or resident, but I did take that route last month. It took me a good 20 minutes driving at roughly 60-70 mph the whole way (with no traffic).
20 minutes from Palo Alto to SFO? I live in Palo Alto and I've never done it in 20 minutes! It can take 5-10 minutes just to get from El Camino Real to 101.
Allocate 40 minutes, as originally suggested. If you are returning a rental car, add at least 20 minutes more. If there's an accident on 101, even on Sunday morning, it will take longer.