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In Italy, the Amalfi Coast and Pompeii would be very difficult, if not impossible. To walk in Venice requires constantly going up and down stairs for the bridges. OTOH, Pisa is small and flat, although you would not want to attempt to climb the leaning tower. Would you feel comfortable renting a car in Italy? If so, you could visit the lakes district, which is gorgeous. Verona and Bologna are relatively close. However, this could be hard to do in ten days when you must take time in Rome for the Vatican. IIRC, it would be hard to see much of the Colisseum.