I use the Motherlode as my "Tech Bag" carry-on when travelling with the family.
Using a number of packing cubes anything electronic we need gets loaded into the bag - laptop, GSM Modem, Mice, Netbook, Kindles, DSi, Wall Warts. Plus travel tickets and all the paperwork you need for a family vacation. Also - books and magazines for the trip for the kids.
I'm a big fan of Ebags and this bag is well made and stands up to a lot of abuse. There's good organisation in the bag, but I would use cubes if putting in clothes. It is also possible to over-stuff the bag, so beware when filling it up for a carry-on.
I personally wouldn't use it as a single bag carry-on: I like my wheels too much and travel with a Mother Lode mini wheeled duffel and an Eastpack messenger bag. For light trips, I stuff the messenger into the duffel.
When with the family, I do use it as a backpack, if I don't have another bag to hang it off. I do, however, have locks when it's on my back.