Originally Posted by
bigmerv
What about Greenwich Village and SoHo?
You could then choose from The (very lovely) Greenwich Hotel (viewed on here as one of the top choices), The Bowery, Crosby Street, Trump Soho, The Jane etc etc - tons of options in a very cool young and vibrant area. The Standard is a party hotel too.
Soho Grand is a good choice in this case as well- the rooms are small however it is a nice hotel overall (don't book the lower categories of rooms).