Good suggestions above, thanks.
IMO, there will be so many changes coming with RR 2.0 that it's hard to envision what tips/tricks might arise. It appears that the nature of the business leads airlines inevitably to come up with promos that can be gamed by people who are so inclined.
Why should WN be any different as it introduces a more complicated rewards program intended to better draw "elite" travelers? I have a feeling that there will be many offers of double and triple points (especially on specific routes/buckets), double TQPs, credit card bonuses, fast-tracks, Partnerpaloozas, partner offers, etc.
In that case, we will all have to follow the Mileage Run forum henceforth, and I agree with ElmhurstNick that "segment running" will likely become very important.