Upintheair,
I stayed at the 4points last September and it's a great property. Does not even compare to the US locations. It's located just off of Avenue Louise in the Southeast section of town. It's about a 10-15 minute walk to the nearest Metro station which is the Louise/Louiza station on Line 2. A metro map is located at
http://www.ib.be/meet/metro.gif . It's only about a $5-6 cab ride from the central train station. There are also intersecting lines of the tram system just outside the hotel. You could easily take the tram to the Louise station if you wish. If you need any more info just let me know.