Definitely yes (gate check) for the ER4, but I think the overheads on the E70 will take the 22" if you slide it sideways. I've never tried it though, and given that I am west coast based, my data points regarding both aircraft are regrettably more limited in comparison to the hated CRJ/CR7, both of which will not accommodate the bag. I think the thickness of the bag could also be an issue.